منابع مشابه
Single cell metrics of the efficacy of CAR T cells
T cells genetically modified to enforce expression of a chimeric antigen receptor (CAR) have shown considerable promise in clinical trials even in tumors refractory to all other treatment methods. In particular, the use of CAR T cells rendered specific for CD19 demonstrated significant anti-tumor effects in patients with CD19 chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (...
متن کاملCAR T- cellها: درمانی هدف‌مند در سرطان
سابقه و هدف: با توسعه و پیشرفت روزافزون در زمینة ایمنی‌درمانی تومورها، امروزه توجه خاصی به درمان‌های ایمنی انواع سرطان‌ها معطوف شده است. درمان‌های بر پایة گیرنده‌های کایمری آنتی‌ژن‌ها (CARs)، یکی از انواع درمان‌های مبتنی بر سلول‌های Tی تغییریافته به‌شمار می‌رود که به‌صورت هدف‌مند تنها روی سلول‌های توموری فرد و نه سلول‌های طبیعی اثر می‌گذارد. مواد و روش‌ها: پژوهش‌ها در دهه‌های اخیر حاکی از این ا...
متن کاملThe man , the key , or the car : Who or what is parked out back ?
Nunberg (1995) has identified two types of metonymic constructions with different linguistic properties: predicate transfer and deferred indexical reference. In this paper, we describe these types of metonymies within the context of cognitive grammar (Langacker, 1999), mental space theory (Fauconnier, 1994), and blending theory (Fauconnier & Turner, 2002). Using concepts from cognitive grammar,...
متن کاملCAR-T: The Current and the Future
Chimeric antigen receptors (CARs) are recombinant receptors that are expressed on autologous T-cells. CAR-T usage has grown in recent years as a way to combat hematological and solid tumors. The purpose of this review is to describe new studies on CAR-T treatment along with our lab’s ideas on potential uses and pitfalls that could be investigated. The usage of TREG and antiCLTA4 as means for re...
متن کاملDesign and development of CAR-T cells for cancer therapy
Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-03-900928